Lightburn works in the +X,+Y quadrant (called Quadrant 1) only. By being at the front-left, you are at 0,0 in the image. From there, all moves are positive numbers (negative is just less positive).
If you move to the Origin position (front left), does the Lightburn X&Y positions show basically X=0 and Y=0? If so, you are good to go with Absolute Coordinates.
HOME and ORIGIN are not the same thing. Home is a machine reference. Origin is a workspace reference. They do not have to be in the same location, and often are not.