Are you using “Send” or “Start” to start off your job on the laser? I can see you are using current position, so if you are using “Start” it should start from where your laser cutters head currently rests.
Your lasers head might have lost position, it is worth pressing reset on the machine itself to ensure your cutter knows where its head is.
I can also see that you are setup on a Bridge system, called Akimbo 2 (always enjoyed that podcast). It could be worth restarting your bridge, to ensure its not an issue there.
All a bit vague, but hopefully we can work it out!