Mint 21 installs the BRLTTY package by default to enable braille user display consoles to connect more easily. But, the BRLTTY package prevents Lightburn from being able to connect to ttyUSB0 port.
SOLUTION: Use Synaptic Package Manager to uninstall ALL BRLTTY related packages and reboot your system.
This is known, and one of the reasons LightBurn is only supported on Ubuntu 20.04. Any other distros are very much your-miles-may-vary.
That said, we’re working on snap packaging to increase linux compatibility across the board!
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