How to set up lightburn to communicate with Lunyee 4050 laser engraver?
That will depend on the motion control system used for this laser. I did not see what controller and firmware is used when I look at their site (did not dig too deep), so we would need to know more to provide an accurate answer. 
You can try it for yourself using our 30-Day free trial downloadable here: Download & Trial - Try before you buy – LightBurn Software
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