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Do you run anti-virus software? (it could be overly aggressive, and might be preventing LightBurn from storing your key information in the registry)
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Do you have anything like registry cleaner software running? (same idea as above)
I know some schools have issues because their systems are set to do a user-level registry wipe every time someone logs out. It would be possible to configure a home machine like this, but it’d be pretty rare.
We have a solution for those cases that would likely work for you as well - it’s possible to have LightBurn enter your key for you by using a command-line procedure. Follow the directions here for “allowing all users on a system to share a system locked license”: