Boss LS1416 Can not get it to communicate to my laser. Using a MAC

Did you search on this forum for “connect with Mac”? There are many topics to explore, and one of them details how ethernet connections are probably the best.
Here is one: How do I connect a Ruida controller with Ethernet?

If you are doing USB, maybe you didn’t need to install the FTDI driver. I didn’t
If you want to get into the weeds of this, look at this macos - How to release/reset serial port FTDI devices - Mac OSX - Super User