Does your machine reset the current position as 0,0 every time you power it on? So basically wherever the laser head happens to be becomes 0,0?
If so, try moving the head to front left before powering on.
It’s also possible that your laser assumes the center of the workspace is 0,0. In that case, refer to how to deal with a negative coordinate machine. LightBurn only wants to work in a positive coordinate space:
Negative Coordinate Machine Setup - Getting Started / Common Problems - LightBurn Software Forum