I have both an xtool and a Ortur Master 2 S2

Can i switch between both my machines with lightburn Shadow?

Could you explain further what is Lightburn shadow?
You can have many devices in your Lightburn program one per instance.

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If you use separate USB ports on the PC, you can run 2 instances of Lightburn independently, one for each machine. You cannot have both machine USB cables into a splitter fed from one PC port.