Did you replace your USB cable with a top quality shielded and ‘choked’ cable?
Did you verify your computer and laser are connected to the exact same AC power outlet?
Did you verify your USB connectors are not loose or in any condition which can cause a poor connection?
Have you tried using a powered USB hub between the computer and the laser? Again powering all from the same AC phase(outlet)?
On the Window side, you’ll have to google for all the things which Windows does to your USB port like powering it down, probing it for virus’s, etc etc.
if you know Linux, make a bootable USB thumbdrive of Ubuntu 18.04 and run Lightburn from that and see if the problem goes away. If not, it’s still a hardware issue, otherwise a software/OS issue.