How big is the image? If it max’es out your workspace, then Overscan can push you off the grid. Turn on the Show traversal moves switch on the Preview window to see if this is the issue. The green frame is the limit of your laser travel.
The image in original format is pretty big, but in my project I have it scaled down to 30x33mm. It’s placed near the lower left, within the bounds of the laser.
Overscanning does seem to be to blame here. As I scale the image up and down, the “overscan amount” doesn’t change, even thought it claims to be a percentage.