The support data generates a puddle of information that can be translated by the kind folks at Support@Lightburnsoftware.com - I don’t believe that it’s necessary to contact them just yet.
First, I believe that one good USB cable from the computer to the Neje engraver should be sufficient.
Have you used the Neje engraver with your Windows 10 computer previously? If so, you will have already installed the CH340 driver and you are on to the next step. If not - please ask and I will help you install the driver.
Start LightBurn and connect your engraver to the computer with one USB cable. You will want to look at two windows ‘Console’ and ‘Laser’.
Look in the Console window to see if you have the welcome message. I point at it with an arrow below.
If you have the welcome message or something similar you are connected. If you are not connected and the console is saying ‘Waiting for connection’ or something similar this is the next step.
In the ‘Laser’ window at the bottom, there are three boxes. You want to be certain that the box at the far right says GRBL and nothing else. Then click the middle bottom button and see what options you have and select a different COM port if you are not yet connected. It is possible that LightBurn wasn’t finding the USB port that was assigned by the computer to the Neje. Wait a few seconds and see if the welcome message now appears in the console window. Repeat this until you see the welcome message or run out of options.
I believe the two usb cable method may be causing problems.