Hey there. The 6445 is basically an updated model of the 6442. I’m working on swapping my Topwisdom controller out with the 6445, so far it has been fairly easy. It is much easier if you can take pictures of the original set up and wire terminations on the Topwisdom so you can accurately transfer the wires. The Topwisdom website also has a machine manual that includes the wiring diagram if you need it. The best comparison of the 6445 and 6442 cards I have found was on the CloudRay website. I hope this helps.